E2A and HEB Activate the Pre-TCR Promoter During Immature T Cell Development
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منابع مشابه
E2A and HEB are required to block thymocyte proliferation prior to pre-TCR expression.
Thymocytes undergoing TCRbeta gene rearrangements are maintained in a low or nonproliferating state during early T cell development. This block in cell cycle progression is not released until the expression of a functional pre-TCR, which is composed of a successfully rearranged TCRbeta-chain and the Pre-Talpha-chain. The regulatory molecules responsible for the coordination of these differentia...
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During specific stages of thymocyte development, the T cell receptor (TCR) locus is assembled from variable (V), diversity (D), and joining (J) gene segments. Proper TCR gamma and delta V(D)J rearrangement during thymocyte development requires the presence of the E2A proteins. Here we show that E2A and a closely related protein, HEB, in the presence of recombination activating gene (RAG)1 and R...
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The expression of the pT alpha gene is required for effective selection, proliferation, and survival of beta T-cell receptor (beta TCR)-expressing immature thymocytes. Here, we have identified two phylogenetically conserved E-boxes within the pT alpha enhancer sequence that are required for optimal enhancer activity and for its stage-specific activity in immature T cells. We have shown that the...
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The expression of the pT gene is required for effective selection, proliferation, and survival of T-cell receptor ( TCR)-expressing immature thymocytes. Here, we have identified two phylogenetically conserved Eboxes within the pT enhancer sequence that are required for optimal enhancer activity and for its stagespecific activity in immature T cells. We have shown that the transcription factors ...
متن کاملFunctions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB.
Lymphocyte development and differentiation are regulated by the basic helix-loop-helix (bHLH) transcription factors encoded by the E2A and HEB genes. These bHLH proteins bind to E-box enhancers in the form of homodimers or heterodimers and, consequently, activate transcription of the target genes. E2A homodimers are the predominant bHLH proteins present in B-lineage cells and are shown genetica...
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تاریخ انتشار 2001